We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Quantity reliance away from currents using solitary sodium-choosy skin pores from inside the frog body. Characteristics. 1979; 282 (5738): 519-520 PubMed Conceptual | Publisher Full Text message
This means this new good conclusions submit through this manuscript try maybe not justified and i also never approve the fresh manuscript contained in this form
The brand new people keeps clarified several of the concerns I increased within the my personal prior review. Sadly, the significant troubles have not been treated by this up-date. Once i manufactured in my earlier comment, I deem it unlikely that most the individuals activities would be fixed merely from the a few extra paragraphs. As an alternative you may still find specific standard questions towards fresh build and you will, extremely critically, for the research.
It means the newest strong conclusions submit through this manuscript was perhaps not justified and i also don’t agree the new manuscript within this means
The fresh writers has actually clarified many of the inquiries We elevated within the my personal previous opinion. Unfortunately, the biggest trouble haven’t been handled from this posting. While i manufactured in my personal past comment, We consider they impractical that men and women issues is going to be fixed simply because of the a number of additional sentences. Alternatively you may still find certain important inquiries into experimental build and you can, really critically, with the research.
- The number one issue is that when I observed the fresh new dysfunction of the methods in the last type it absolutely was possible so you can decode, which have nearly best precision, one random stimulus names We selected. Pick to own samples of this reanalysis. No matter whether we pretend that the genuine stimulus appeared within an afterwards go out otherwise is consistently alternating between rule and you will silence, the new decryption is close to perfect. This will be indicative the decoding has nothing to-do towards the actual stimuli read by Sender but is opportunistically exploiting different enjoys throughout the research. The latest control study the brand new article authors did, reversing the fresh new stimulus labels, do not address this matter because it suffers from similar state. Fundamentally, what the classifier is actually allegedly playing with it’s time having enacted due to the fact recording been.
- The reason behind this really is presumably your authors put low-independent investigation for studies and research. While I am aware truthfully (look for section step three), random testing 1 / 2 of information examples away from an enthusiastic EEG shade aren’t separate studies. Recurring the study five times the brand new control analysis the brand new people did is not a sufficient way to address that it concern. At random looking products of a time show that has slow alter (like the sluggish revolution activity one to presumably dominates these tracks not as much as these situations) have a tendency to inevitably contain solid temporal correlations. Get a hold of TemporalCorrelations.jpg in for 2D occurrence histograms and a relationship matrix proving this.
- Due to the fact changed steps area will bring more detail now, they is still confused about what studies were utilized. Conventional classification data statement exactly what studies possess (usual articles throughout the data matrix) and you can what observations (usual rows) were used. Something might possibly be a component however, generally speaking this might be the latest some other EEG channels or fMRI voxels etcetera. Observations usually are date factors. Here I guess the latest writers turned the fresh new raw examples for the an excellent some other space playing with dominant part data. That isn’t said in case your dimensionality was less utilizing the eigenvalues. In any event, I assume the information samples (obtained at 128 Hz) were then used as findings and EEG channels transformed by PCA were used since the has actually. The fresh new stimulus names was indeed tasked since the Into the or Of for every shot. Some 50% out of products (and labels) ended up being picked randomly getting studies, plus the rest was used having investigations. Is it proper?
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